Splashtop does NOT work in safe mode on Windows XP and Windows Server 2003.
Splashtop does work in safe mode for Windows 7 and higher and Windows Server 2008 and higher.
This means the Splashtop streamer can auto-launch in safe mode. If network is available, a remote session can also be established to it.
We expect to roll out remote reboot (via web console) within 3 months.
In the meantime, here's a great suggestion from a fellow user. (Thank you Gsteph2008!)
"As I stated on May 22nd (under my jackson-computers previous login), you can utilize Safe Mode with Network & even on XP. It is a minor inconvenience to go into MSCONFIG (Boot Tab) & temporarily check the Safe Mode & Network boxes & then uncheck them when finished to go back into Normal Mode. This will allow you to use Safe Mode until the Splashtop Developers finish their development & give you an 'easy button'. I have been with Splashtop for a long time & have seen a major improvement. Have patience everyone, & in the meantime do use Splashtop in Safe Mode with the MSCONFIG method."